|
KMID : 1141820180180040409
|
|
Journal of Gastric Cancer
2018 Volume.18 No. 4 p.409 ~ p.416
|
|
|
Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report
|
|
Okumura Yasuhiro
Takamatsu Manabu
Ohashi Manabu
Yamamoto Yorimasa
Yamamoto Noriko
Kawachi Hiroshi
Ida Satoshi
Kumagai Koshi
Nunobe Souya
Hiki Naoki
Sano Takeshi
|
|
|
Abstract
|
|
|
|
A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG.
|
|
|
KEYWORD
|
|
|
Gastric gland, Lymph nodes, Neoplasm metastasis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|